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. 2022 Apr 5;8:164. doi: 10.1038/s41420-022-00925-6

Fig. 7. The molecular mechanism of gastric cancer (GC) cell-derived extracellular vesicles (EVs) in peritoneal metastasis of GC.

Fig. 7

Note: gastric cancer cell-derived extracellular vesicles elevate E2F7 expression and activate the MAPK/ERK signaling to promote peritoneal metastasis through the delivery of SNHG12. SNHG12 lncRNA small nucleolar RNA host gene 12, miR-129-5p microRNA-129-5p, E2F E2F transcription factor 7, MAPK mitogen-activated protein kinase, ERK extracellular regulated protein kinase.