TABLE 4.
Studies of normothermic machine perfusion for hearts from donation after circulatory death.
| Study | Number of patients | Outcomes | Publication type |
|---|---|---|---|
| Chew et al., 2017 (36) | DCD = 12, MBD = 12 | All hearts retrieved with DPP, comparable survival rate between OCS-preserved DCD hearts and OCS-preserved MBD hearts | Conference abstract |
| Chew et al., 2019 (22) | DCD = 23, DBD = 94 | All DCD hearts retrieved with DPP, comparable survival rate between OCS-preserved DCD hearts and SCS-preserved DBD hearts | Paper |
| Dhital et al., 2015 (23) | DCD = 3 | All hearts retrieved with DPP, survival to date: 77, 91, and 176 days | Article |
| Garcia et al., 2016 (17) | DCD = 2 | Both hearts retrieved with DPP, survival to date: 290 and 291 days | Article |
| Mehta et al., 2019 (18) | DCD = 7 | All hearts retrieved with DPP, 90-day survival rate 86% | Article |
| Messer et al., 2016 (20) | DCD = 9 | 8 hearts retrieved with TA-NRP + OCS; all patients survived during follow-up (range, 48–297 days) | Article |
| Messer et al., 2017 (24) | DCD = 26, DBD = 26 | DCD hearts retrieved with DPP or TA-NRP, comparable results of the OCS-preserved DCD hearts and the SCS-preserved DBD hearts | Article |
| Messer et al., 2019 (37) | DCD = 50, DBD = 50 | DCD hearts retrieved with DPP or TA-NRP, comparable results in 30-day survival | Conference abstract |
| Mohite et al., 2019 (19) | DCD = 1 | Heart retrieved with DPP, alive to date at 5 months | Article |
| Page et al., 2017 (38) | DCD = 20, DBD = not reported | Biopsies within first month after transplantation showed significantly lower positive C4d rate in OCS-preserved DCD hearts suggesting a lower IRI rate. During first year, acute cellular rejection (2R) was lower in DCD than DBD group | Conference abstract |
| Page et al., 2018 (39) | DCD = 31, DBD = 31 | DCD hearts retrieved with DPP or TA-NRP, comparable results | Conference abstract |
DBD, donation after brainstem death; DCD, donation after circulatory death; DPP, direct procurement and perfusion; IRI, ischemia reperfusion injury; MBD, marginal brain dead; TA-NRP, normothermic regional perfusion; OCS, organ care system; SCS, static cold storage.