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. 2022 Mar 23;13:821189. doi: 10.3389/fneur.2022.821189

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Copyright © 2022 Marsili, Duque, Bode, Kauffman and Espay.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Main differences between short-read next-generation sequencing (NGS) and long-read sequencing (LRS) technologies. Short-read NGS (upper panel) uses PCR to obtain short DNA fragments that do not accurately cover the whole repeated DNA sequence, thus allowing many interpretation errors (e.g., including edge of repeat and flanking regions, spanning boundaries of repeats). The differing technology of LRS (lower panel) does not require PCR, allowing a more accurate coverage of the repeated DNA sequence. Created with BioRender.com.