TABLE 5.
Multivariate logistic regression analysis for prediction of MVI in patients undergoing LT for HCC.
| Tot | MVI | No MVI | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|---|
| Odds ratio (95% CI) | p-value | Odds ratio (95% CI) | p-value | ||||
| Overall n (%) | 159 (100) | 31 (19.5) | 128 (80.5) | ||||
| Age >60 (%) | 81 (50.9) | 14 (17.3) | 67 (82.7) | 0.74 (0.34–1.64) | 0.47 | ||
| BMI >30 (%) | 37 (23.2) | 27 (73) | 10 (27) | 1.78 (0.74–4.22) | 0.17 | ||
| Cirrhosis etiology (%) | |||||||
| HCV | 55 (34) | 6 (11) | 49 (89) | 0.38 (0.14–1.02) | 0.10 | ||
| HBV | 10 (6) | 3 (30) | 7 (70) | 1.85 (0.45–7.61) | 0.28 | ||
| Alcoholic | 75 (47) | 14 (18.6) | 61 (81.4) | 0.90 (0.41–1.98) | 0.74 | ||
| NASH | 11 (7) | 2 (18.2) | 9 (81.8) | 0.91 (0.18–4.44) | 0.95 | ||
| Other | 8 (6) | 3 (37.5) | 5 (62.5) | 2.63 (0.59–11.6) | 0.13 | ||
| Waiting time, mean (SD) | 6.78 (±5.75) | 7.07 (±5.77) | 7.38 (±5.79) | 1.003 (0.96–1.04) | 0.78 | ||
| No treatments during waiting time (%) | 40 (25.1) | 10 (25) | 30 (75) | 1.55 (0.66–3.66) | 0.31 | ||
| Tumor size >30 mm (%) | 17 (10.7) | 6 (35) | 11 (65) | 2.55 (0.86–7.55) | 0.08 | 1.49 (0.39–5.7) | 0.18 |
| Tumor nodules pre-LT ≥3 (%) | 53 (33.3) | 10 (19) | 43 (81) | 0.94 (0.40–2.17) | 0.30 | ||
| Child- Turgot- Pugh (%) | |||||||
| A | 79 (49.6) | 18 (22.7) | 61 (77.7) | 1.52 (0.68–3.36) | 0.29 | ||
| B | 52 (32.7) | 7 (13.4) | 45 (86.6) | 0.53 (0.21–1.34) | 0.18 | ||
| C | 28 (17.6) | 6 (21.5) | 22 (78.5) | 1.15 (0.42–3.15) | 0.77 | ||
| MELD, median (IQR) | 11 (±9) | 11 (±6) | 11 (±9) | 0.97 (0.90–1.04) | 0.42 | ||
| AFP pre-LT ng/ml, median (range) | 6.65 (1–1,170) | 12.7 (1.2–1,170) | 5.3 (1–373) | 1.02 (0.99–1.03) | 0.07 | 1.03 (0.98–1.05) | 0.34 |
| Within Milan criteria (%) | 114 (71.6) | 19 (16.6) | 98 (83.4) | 0.48 (0.21–1.11) | 0.08 | 0.17 (0.01–1.18) | 0.21 |
| Delta AFP SCORE progression | 34 (21.3) | 18 (53) | 16 (47) | 9.69 (3.9–23.4) | <0.0001 | 10,79 (CI = 2.35–49.4) | 0.002 |
Bold values represent statistically significant results
BMI, body mass index; HCV, hepatitis C virus; HBV, hepatitis B virus; NASH, non-alcoholic steatohepatitis; LT, liver transplantation; MELD, model for end stage liver Disease; AFP, alpha fetoprotein; MVI, microvascular invasion. OR, odds ratio; CI, confidence interval. Variables with p-value <0.10 underwent multivariate analysis.