Figure 10.

Tractable evidence for targeting neutrophil degranulation based on genes prioritized specific to endometriosis in the cluster C5. (A) Heatmap illustrates target genes in C5 prioritized across 7 diseases, together with the information on functional relevance to neutrophil degranulation, the tractability (the number of druggable pockets), and therapeutic approval (approved drug targets, repurposed drugs, mechanisms of action, and disease indications). (B) Druggable pockets for genes prioritised specific to endometriosis in C5. Dot plot shows 11 tractable genes involved in neutrophil degranulation (y-axis) and their PDB known protein structures (x-axis). Color-coded is the number of druggable pockets predicted based on the PDB structure. On the right is an exemplar illustrating an experimentally resolved WAVE regulatory complex coded as ‘4N78’ in PDB. This structure consists of 5 genes including CYFIP1, where two druggable pockets are predicted (as indicated in blue balls and labelled as well).