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. 2022 Mar 23;13:867358. doi: 10.3389/fphys.2022.867358

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Copyright © 2022 Shimura and Shaw.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic summary of GJA1-20k. GJA1-20k is generated by internal translation of Gja1 mRNA. GJA1-20k works not only as an auxiliary trafficking subunit for full-length Cx43 hemichannels to cell-cell borders but also as an actin stabilizer. In mitochondria, GJA1-20k is upregulated by ischemic/oxidative stress and works with actin to induce a protective mitochondrial fission.