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. 2022 Mar 23;13:847905. doi: 10.3389/fphar.2022.847905

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Copyright © 2022 Bai, Chen, Hu, Wang, Wu and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silibinin inhibits cell viability in cholangiocarcinoma cells. (A). Diagram of the three-dimensional structure of silibinin. (B). Silibinin inhibited cell viability of HuCCT-1 and CCLP-1 cell lines in a concentration-dependent and time-dependent manner. Cells were treated with varying concentrations of silibinin for indicated time points (6, 12, 24, 48 and 72 h) and cell viability was examined by the CCK-8 assay. (C). Colony formation assay results of HuCCT-1 and CCLP-1 cell lines treated with different concentrations of silibinin. (D). EdU proliferation assay results of HuCCT-1 and CCLP-1 cell lines treated with different concentrations of silibinin.