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. 2022 Mar 23;13:847905. doi: 10.3389/fphar.2022.847905

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Copyright © 2022 Bai, Chen, Hu, Wang, Wu and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The combined application of SCH772984 significantly aggravated apoptosis of cholangiocarcinoma cells. (A,B). Apoptosis detection by FCM and quantitative analysis of the apoptosis rate. (C,D). The expression of apoptosis-related proteins was identified in HuCCT-1 and CCLP-1 cell lines, and quantification results were shown by histograms. Data is shown as mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, significantly difference compared to the control group. #p < 0.05, ##p < 0.01, ###p < 0.001, significantly difference compared to the SIL group.