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. 2022 Mar 23;9:849990. doi: 10.3389/fmed.2022.849990

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Copyright © 2022 Alam, Yazdanpanah, Ratnapriya, Borcherding, de Paiva, Li, Guimaraes de Souza, Yu and Pflugfelder.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of RXRα mediated suppression of IL-17 production by γδ T cells and IL-17 mediated dry eye disease. RXRα suppresses the production of IL-17 inducers (IL-23, IL-1β, and TNF-α) by myeloid cells and directly suppresses IL-17 production by activated γδ T cells. IL-17 promotes corneal barrier disruption, increased expression of the cornified envelope precursor SPRR2 that decreases epithelial lubricity and seals goblet cell openings and reduction in mucin-filled conjunctival goblet cells.