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. 2022 Mar 23;13:812338. doi: 10.3389/fphar.2022.812338

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Copyright © 2022 Ngai, Kalter, Byrd, Racz and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of significant cardiovascular AEs for CQ and HCQ from the FAERS database. (A) Venn Diagram of significant cardiovascular AEs for CQ and HCQ. (B) OAE classification of 10 significant cardiovascular AEs for CQ. (C) OAE classification of 6 significant cardiovascular AEs for HCQ. The red sign of “X” next to the AE terms in (B,C) represent the shared AE for CQ and HCQ. Note that cardiac disorder AE passed the significance threshold for CQ (A) but not for HCQ (B). Overall CQ was associated with more cardiovascular AEs.