Table 1.

Summary of cases of DIE malignant transformation.

Reference	Age	Clinical presentation	Invasion site	Surgery	Pathological type	Adjuvant therapy	Outcome
Yang et al. (9)	57	vaginal bleeding, left lower abdominal pain	Douglas cul-de-sac	RAU + BAR + LE + OE + AE + PRR + OS	EC	CT	DFS: 12 mo
Marchand et al. (14)	63	pelvic discomfort, abdominal distension	rectovaginal septum	TR + UTER + BAR + LE + OE	EC		DFS:18 mo
Kim et al. (15)	40	No	rectovaginal septum	TR + RAU + PRR	EC	HRT	DFS: 8 mo
Ota et al. (16)	48	pelvic pain	Uterosacral ligament	UTER + OE + LE+	EC	CT	DFS: 2 yr
Mabrouk et al. (17)	36	abdominal discomfort	rectovaginal septum	RAU + LE + OE + AE + PRR + OS	EC	CT	DFS: 2 mo
Verma et al. (18)	49	sudden onset abdominal pain	Caecum	radical right hemicolectomy	EC	No	Loss of follow-up
Kondo et al. (19)	52	genital bleeding	vaginal	No	CCC	CT	R: 11 yr (Surgery: CCC)
Tarumi et al. (20)	45	frequent urination and miction pain	bladder	UTER partial bladder resection	EC	CT	DFS: 10 mo

RAU, Radical uterectomy; BAR, Bilateral adnexal resection; UAR, Unilateral adnexal resection; LE, Lymphadenectomy; UTER, Uterectomy; PRR, partial rectal resection; OS, ostomy; OE, Omentectomy; TR, Tumor resection; AE, Appendectomy; RT, Radiotherapy; CT, Chemotherapy; HRT, Hormone therapy; CRT, Chemo-and radio-therapy; DFS, Disease free survival; DOD, Dead of disease; LWD, Living with disease; R, Recurrence; EC, Endometrioid adenocarcinoma; CCC, clear-cell carcinoma.