Table 4.
Interaction between miRNAs and PDCD in female cancers.
| Cancer | miRNA | Animal-human | Cell lines | Targets | Pathways | Function | Ref |
|---|---|---|---|---|---|---|---|
| Cervical Cancer (CC) |
miR-150 | 50 pairs of CC and adjacent normal tissues | HeLa, SiHa | PDCD4 | – | Upregulation of miR-150 by targeting PDCD4 could enhance cell migration, invasion, and proliferation. | (44) |
| CC | miR-21 | – | C−33A, CaSki, SiHa, HeLa, ME−180, H8 | PDCD4, Bcl-2, Bax, c-myc, PTEN |
AKT | Downregulation of miR−21 by targeting PDCD4 and regulating the PTEN/AKT could inhibit cell proliferation and colony formation in CC cells. | (48) |
| CC | miR-21 | – | HeLa | PDCD4 | – | Upregulation of miR-21 by targeting PDCD4 could enhance cell proliferation in CC cell lines. | (45) |
| Ovarian Serous Carcinoma (OSC) | miR-21 | 14 OSC, 14 serous cystadenoma (CA), and 14 normal ovaries from cases of uterine prolapse | – | PDCD4 | – | Upregulation of miR-21 by targeting PDCD4 could result in OSC oncogenesis. | (46) |
| Ovarian Cancer (OC) |
miR-182 | 13 OC tissues and 2 normal control tissues | T29, T80, OVCAR3, SKOV3, OV2008, HEY, 3AO, A2780, HO8910, C13 | PDCD4 | – | Upregulation of miR-182 by targeting PDCD4 could enhance cell growth, invasion, and chemoresistance in human OC. | (49) |
| Breast Cancer (BCa) | miR-21 | 60 BCa tissues and blood samples and blood samples from 30 normal volunteers | – | PDCD4 | – | Upregulation of miR-21 by translational repression of the PDCD4 could promote breast cell transformation and the development of BCa. | (47) |
| BCa | miR-421 | 52 BCa tissue samples and 52 normal tissue samples | MCF-7, MDA-MB-231, Hs578bst | PDCD4 | – | Downregulation of miR−421 by targeting PDCD4 could reduce cell proliferation, migration potential, and invasiveness, and enhance apoptosis in BCa cell lines. | (50) |
| BCa | miR-27a-3p | 26 pairs of BCa and adjacent normal tissues | MCF-7, BT474, MDA-MB-23, MCF-10A, THP-1 | PD-L1, MAGI2, PTEN, GRP78, PERK, ATF6, IRE1α, IL-2 | PI3K/AKT | Upregulation of miR-27a-3p by targeting PD-L1 through MAGI2/PTEN/PI3K axis could enhance immune evasion in BCa. | (51) |
| BCa | miR-26a-5p, miR-26b-5p | Male nude mice/Human: 20 pairs of BCa and adjacent normal tissues | T24, 5637 | PDCD10 | – | Upregulation of miR-26a-5p and miR-26b-5p by regulating PDCD10 could suppress the BCa cell lines proliferation. | (52) |
| Triple-Negative Breast Cancer (TNBC) | miR-424-5p | Female Balb/c athymic nude mice | MCF10A, BT474, HCC1500, 293T, HCC1806, HCC1954, MM231 | PD-L1 | – | Upregulation of miR-424-5p by targeting PD-L1 could enhance the secretion of pro-inflammatory cytokines, reduce the secretion of anti-inflammatory cytokines and boost the apoptosis of tumor cells. | (53) |