Table 8.

Interaction between miRNAs and PDCD nervous system cancers.

Cancer	miRNA	Animal-human	Cell lines	Targets	Pathways	Function	Ref
Malignant Peripheral Nerve Sheath Tumor (MPNST)	miR-21	12 MPNSTs, 11 neurofibroma, 5 normal nerves	HS-Sch-2, YST-1, NMS-2	PDCD4	–	Downregulation of miR-21 by targeting PDCD4 could induce cell apoptosis of MPNST cells.	(85)
Glioblastoma (GBM)	miR-96	–	U87-MG, T98G U251-MG, A172	PDCD4		Upregulation of miR-96 by targeting PDCD4 could improve radioresistance in GBM cells.	(88)
GBM	miR-21	13 pairs of GBM and normal brain tissue samples	SNB19, U251, U87, SF767	PDCD4	–	Downregulation of miR-21 could reduce proliferation, enhance apoptosis, and suppress anchorage-independent growth in glioblastoma-derived cell lines.	(86)
Neuroblastoma (NB)	miR-21	–	SK-N-SH, SH-SY5Y, BE2C, 293T	PDCD4, PTEN	–	Downregulation of miR-21 by targeting PTEN/PDCD4 could result in SK-N-SH cell apoptosis and suppress proliferation in NB.	(87)
Retinoblastoma	miR-181b	–	HXO-RB44, HUVECs	PDCD10, HIF-1α, GATA6	–	Upregulation of miR-181b which is induced by hypoxia could increase angiogenesis of retinoblastoma cells by regulating PDCD10 and GATA6.	(89)