TABLE 4.

Risk of Hypersensitivity Reactions and Adjusted Odds Ratios of Significant Covariates in Analysis I

	Cases, n = 818 (%)	Controls, n = 132,032 (%)	Odds Ratio	95% CI	P
Age group (vs adults)	640 (78.2)	86,023 (65.2)
Children	14 (1.7)	2964 (2.2)	0.58	0.34–0.98	0.043
Elderly	164 (20.0)	43,045 (32.6)	0.51	0.43–0.61	<0.001
Sex (vs male)	411 (50.2)	74,575(56.5)
Female	407 (49.8)	57,457 (43.5)	1.16	1.01–1.34	0.032
Injection route (vs intravenous injection)	762 (93.2)	104,257 (79.0)
Intra-arterial	56 (6.8)	27,775 (21.0)	0.49	0.35–0.70	<0.001
Diabetes mellitus (vs no)
Yes	68 (8.3)	10,316 (7.8)	1.57	1.22–2.03	<0.001
Allergy (vs no)
Yes	82 (10.0)	3477 (2.6)	3.73	2.93–4.74	<0.001
Asthma bronchial (vs no)
Yes	15 (1.8)	805 (0.6)	2.14	1.26–3.63	0.005
Contrast media reaction (vs no)
Yes	22 (2.7)	695 (0.5)	4.28	2.74–6.70	<0.001
Other (vs no)
Yes	152 (18.6)	19,182 (14.5)	1.37	1.14–1.64	<0.001

95% Confidence intervals (CIs) are constructed using asymptotic Wald confidence limits without correction.

P value from Wald test.