Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 5;10(4):e002944. doi: 10.1136/jitc-2021-002944

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Schematic diagram of a novel immunotherapy-based comprehensive strategy combined with SERMs/SERDs, transforming growth factor-β (TGF-β) or Wnt antagonists for PC-targeting therapy. The SERMs/SERDs increase immune cell infiltrations, including natural killer (NK) cells, CD8 +T cells, CD4 +T cells, dendritic cells (DCs) and neutrophils, and decrease immunosuppressive cancer associated fibroblasts (ICAFs), tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) by altering the activity of downstream pathways and synergizing with other agents.