TABLE 1.
Demographic and clinical characteristics
| CU (n = 223) | MCI (n = 91) | Dementia (n = 83) | |
|---|---|---|---|
| Age | 75.2 (5.70) | 73.6 (7.99) | 70.7 (7.91)* , + |
| Gender, N male (%) | 101 (45.3%) | 51 (56.0%) | 49 (59.0%) |
| Education (years) | 14 (3.0) | 12.5 (3.1)* | 12 (3.0)* |
| APOE ε4+ (%) | 72 (32.3%) | 46 (50.5%)* | 46 (55.4%)* |
| MMSE, median (IQR) | 29 (2.00) | 27 (4.00)* | 23 (4.00)* , + |
| CDR SoB, median (IQR) | 0.0 (0.00) | 1.0 (1.50)* | 4.0 (1.00)* , + |
| AIBL PACC, mean (SD) | −0.4 (0.84) | −2.4 (1.12)* | −4.3 (2.39)* , + |
| Centiloid, mean (SD) | 19.5 (38.11) | 72.8 (66.16)* | 93.9 (55.58)* , + |
| Aβ+, N (%) | 46 (20.6%) | 56 (61.4%)* | 68 (81.9%)* , + |
| MK6240 SUVRMT, mean (SD) | 1.02 (0.23) | 1.48 (0.61)* | 1.93 (0.77)* , + |
| TauMT+, N (%) | 31 (13.9%) | 48 (52.7%)* | 64 (77.1%)*, + |
| Adjusted HV (SD) | 2.98 (0.26) | 2.78 (0.40)* | 2.57 (0.42)* , + |
| Plasma p217+tau, mean (SD) | 87.8 (67.8) | 183.7 (141.0)* | 229.9 (150.7)* , + |
Abbreviations: CU, cognitively unimpaired; MCI, mild cognitive impairment. the total number of individuals (N), positive Aβ scan (Aβ+), SUVR in the Meta Temporal region (SUVRMT)
*
P‐value < .05 compared to CU.
+
P‐value < .05 compared to MCI.
AIBL PACC is the AIBL preclinical Alzheimer's cognitive composite; MMSE is the Mini‐Mental State Examination, CDR‐SoB is the Clinical Dementia Rating Scale Sum of Boxes, TMT+ means positive for tau in the tau PET meta temporal ROI; HV is hippocampal volume.SD and IQR are respectively the standard deviation and the interquartile range.