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. 2022 Mar 23;10:869860. doi: 10.3389/fchem.2022.869860

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Copyright © 2022 Lin, Liu, Zhao, Han, Li, Ye and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Synthesis of phenyl substituted 3-hydroxypyridin-2(1H)-ones as endonuclease inhibitors. (B) From hit to lead for inhibitors of influenza PA endonuclease. (C) Antiviral activity of 2-ONN-based nucleoside analogs. (D) 2-pyridinone derivatives as inhibitors against HBV DNA replication and hepatitis B e-antigen (HBeAg) separately. (E) Design of pyridin-2(1H)-ones as NNRTIs by using a scaffold hopping approach (Benjahad et al., 2004). (F) Biological activity of IOPY and ISPY analogs (Benjahad et al., 2007). (G) Optimization of pyridinone-based NNRTIs. (H) SAR of pyridin-2(1H)-ones as inhibitors of HIV reverse transcriptase. (I) Optimization of 1,5-dibenzyl-2-pyridinones as InSTIs.