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. 2022 Mar 23;13:832547. doi: 10.3389/fgene.2022.832547

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Copyright © 2022 Vidya and Duchaine.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Domain organization of the decapping holocomplex in various organisms. The decapping holocomplex is composed of Dcp2 and Dcp1. (A) Dcp2 is the catalytic subunit that contains the catalytic core composed of the Nudix hydrolase domain and Box A. The N- and C-terminal ends are regulatory domains mainly composed of intrinsically disordered regions which vary in length and sequence in different species. (B) Dcp1 is the main activator of Dcp2 and is characterized by a conserved EVH1 domain. Metazoan Dcp1 acquires an intrinsically disordered extension in the C-terminus and can form a trimer. Abbreviations: IDR = Intrinsically Disordered Region; IM = Inhibitory Motif; HLM = Helical Leucine-rich Motif; EVH1 = Enabled/Vasodilator-stimulated Phosphoprotein Homology 1.