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. 2022 Mar 23;13:832547. doi: 10.3389/fgene.2022.832547

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Copyright © 2022 Vidya and Duchaine.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Domain organization of various decapping activators. The archetypal domain organization of (A) Edc1, (B) Edc2, (C) Edc3, (D) Edc4, (E) Pby1, (F) PatL1, (G) 4E-T, (H) Lsm14 and (I) Ddx6 are illustrated. Depicted are the S. cerevisiae orthologs of Edc1, Edc2 and Pby1, and the H. sapiens orthologs of the other decapping activators. Conserved domains and motifs are highlighted, and species-specific features are discussed in the main text. Abbreviation: IDR = Intrinsically Disordered Region.