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. 2022 Mar 23;13:827016. doi: 10.3389/fphar.2022.827016

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Copyright © 2022 Zhang, Song, Zhao, Tao, Zhang, Sun, Wang, Wang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Illustrative diagram of the experiment. Protocol I: Behavioral tests were performed on days 0, 1, 3, 7, 10, and 14 post-SNI. Protein was removed from the L4-6 lumbar enlargement of the spinal cord for biological tests on day 14 post-SNI. Protocol II: A day before SNI, Ad-SIRT2 or Ad-control was injected intrathecally. Behavioral tests were performed on days 0, 1, 3, and 7 post-SNI. Tissue samples were harvested on day 7 post-SNI. SNI: spared nerve injury; IT: intrathecal injection of SIRT2 adenovirus (Ad-SIRT2) or Ad-control; blue arrow: Behavioral test.