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. 2022 Mar 23;13:827016. doi: 10.3389/fphar.2022.827016

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Copyright © 2022 Zhang, Song, Zhao, Tao, Zhang, Sun, Wang, Wang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The paw withdrawal threshold (PWT) decreased in the SNI rats, and the levels of SIRT2 and FPN1 were downregulated in the SNI rats. (A) The PWT values to mechanical stimulation on days 0, 1, 3, 7, 10, and 14 after sham operation or SNI. (B) Time-dependent changes in the expression of SIRT2 in the spinal cord of the SNI rats. (C) Time-dependent changes in the expression of FPN1 in the spinal cord of the SNI rats. The rats in the sham operation group were used as controls. Values are expressed as the mean ± SE (n = 5 per group). *p-values of <0.05, **p-values of <0.01, and ***p-values of <0.001 for comparisons with values of the sham rats or SNI rats at baseline (day 0). SNI, spared nerve injury; SIRT2, sirtuin 2; FPN1, ferroportin 1.