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. 2022 Mar 23;13:827016. doi: 10.3389/fphar.2022.827016

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Copyright © 2022 Zhang, Song, Zhao, Tao, Zhang, Sun, Wang, Wang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The cellular localization of SIRT2 and FPN1 in the spinal cord. (A) SIRT2 levels decreased in the microglia of SNI rats. (B,C) FPN1 levels decreased in the microglia and neurons of SNI rats. The image in the first column on the left shows the overall outline of the spinal cord. Representative confocal images show the results of double immunofluorescence staining of SIRT2 or FPN1 (red) in the spinal dorsal horn; CD11b, a microglia marker (green) or NeuN, a neuronal marker (green) in the sham group and SNI group. Scale bars, 100 μm. SNI, spared nerve injury; SIRT2, sirtuin 2; FPN1, ferroportin 1.