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. 2022 Mar 23;13:827016. doi: 10.3389/fphar.2022.827016

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Copyright © 2022 Zhang, Song, Zhao, Tao, Zhang, Sun, Wang, Wang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intrathecal injection of SIRT2 adenovirus attenuated mechanical allodynia in SNI rats, enhanced the expression of FPN1, and reduced iron accumulation induced by SNI. (A) The effects of the intrathecal injection of Ad-SIRT2 or Ad-control on PWT in the sham group or SNI group. (B) Changes to SIRT2 expression in the spinal cord after an intrathecal injection of Ad-SIRT2 or Ad-control. (C) Changes to FPN1 expression in the spinal cord after an intrathecal injection of Ad-SIRT2 or Ad-control. The rats in the sham operation group were used as controls. (D) Changes to iron concentration in the spinal cord after an intrathecal injection of Ad-SIRT2 or Ad-control. Values are expressed as the mean ± SE (n = 5 per group). *p-values of <0.05 and **p-values of <0.01 for comparisons with sham rats or baseline values of the SNI rats (day 0); #p-values of <0.05 and ##p-values of <0.01 for comparisons with SNI or Ad-control rats. SNI, spared nerve injury; SIRT2, sirtuin 2; FPN1, ferroportin 1.