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. 2022 Mar 23;13:827016. doi: 10.3389/fphar.2022.827016

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Copyright © 2022 Zhang, Song, Zhao, Tao, Zhang, Sun, Wang, Wang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intrathecal injection of SIRT2 decreases lipid peroxidation in the spinal cord of SNI rats. (A) Changes to NRF2 expression in the spinal cord after an intrathecal injection of Ad-SIRT2 or Ad-control. The rats in the sham operation group were used as controls. Changes to MDA (B) and SOD (C) expression in the spinal cord after an intrathecal injection of Ad-SIRT2 or Ad-control. The rats in the sham operation were used as the control group. Values are expressed as the mean ± SE (n = 5 per group). *p-values of <0.05 and **p-values of <0.01 for comparisons with sham rats or baseline values of the SNI rats (day 0); #p-values of <0.01 and ##p-values of <0.01 for comparisons with SNI or Ad-control rats. SNI, spared nerve injury; SIRT2, sirtuin 2; NRF2, nuclear factor erythroid 2-related factor 2; MDA, malondialdehyde; SOD, antioxidant enzyme superoxide dismutase.