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. 2022 Mar 23;13:827016. doi: 10.3389/fphar.2022.827016

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Copyright © 2022 Zhang, Song, Zhao, Tao, Zhang, Sun, Wang, Wang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intrathecal injection of SIRT2 increased the levels of GPX4 and decreased the levels of ACSL4. (A) Changes to GPX4 expression in the spinal cord after an intrathecal injection of Ad-SIRT2 or Ad-control. (B) Changes to ACSL4 expression in the spinal cord after an intrathecal injection of Ad-SIRT2 or Ad-control. The rats in the sham operation group were used as controls. Values are expressed as mean ± SE (n = 5 for each group). *p-values of <0.05 and **p-values of <0.01 for comparisons with sham rats or baseline values of the SNI rats (day 0); ##p-values of <0.01 for comparisons with SNI or Ad-control rats. SNI, spared nerve injury; SIRT2, sirtuin 2; GPX4, glutathione peroxidase 4; ACSL4, anti-acyl-coenzyme A synthetase long-chain family member 4.