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. 2022 Mar 23;13:826792. doi: 10.3389/fphar.2022.826792

FIGURE 1.

FIGURE 1

EMPA reduced SBP and ACR and induced glycosuria and natriuresis in an AT1-AA-infused mouse model. (A) Schematic illustration of animal experiments. (B) Systolic blood pressure (SBP) recorded from GD13 to GD18 of control or PE mice treated with EMPA or losartan (n = 12). (C) Urinary albumin to creatinine ratio (ACR) on GD11 and GD19 in control and PE mice (n = 12). (D,E) Mouse body weight and blood glucose recorded from GD13 to GD18 in each group (n = 12). Mouse serum BUN (F) (n = 3), urine glucose excretion (G) (n = 12) and urine sodium excretion (H) (n = 12) of each group. Data are expressed as the mean ± SEM and were analyzed by ANOVA with LSD post hoc test. *p < 0.05, **p < 0.01, ***p < 0.001.