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. 2022 Mar 23;13:848897. doi: 10.3389/fphar.2022.848897

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Copyright © 2022 Yin, Nian, Wang, Wu, Wu, Zhao, Cao, Wu and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–I) Cu²⁺ fluorescence intensity of copper-laden HLD hepatocytes treated with GDD by fluorescence microscope (magnification = ×100); (J) effect of GDD on content of Cu²⁺ in copper-laden HLD hepatocytes ( $\bar{x} \pm s, n = 6$ ). ^# p < 0.05, ^## p < 0.01 compared with control group; ^* p < 0.05, ^** p < 0.01 compared with shATP7B + Cu group.