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. 2022 Mar 23;10:833663. doi: 10.3389/fcell.2022.833663

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Copyright © 2022 Del Giudice, De Luca, Parizadeh, Russo, Luini and Di Martino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Golgi proteins roles in tumor dissemination and invasion. Golgi proteins are involved in multiple processes linked to tumor aggressiveness, such as the secretion of MMPs, cell migration and regulation of apico-basal polarity, and their roles have been assessed in different tumors. This picture summarizes the different Golgi signaling proteins involved in regulating specific MMPs secretion, the Golgi-localized proteins that are part of the CDC-42 complex for directed cell migration, and finally the PKD signaling pathway that promotes the maintenance of apico-basal polarity.