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. 2022 Mar 23;13:852941. doi: 10.3389/fphar.2022.852941

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Copyright © 2022 Colapietro, Yang, Rossetti, Mancini, Vitale, Chakraborty, Martellucci, Marampon, Mattei, Gravina, Iorio, Newman and Festuccia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Long term effects of PBI-05204 on radio-sensitivity of GBM cells. Cells were treated with PBI-05204 (2.5 and 5.0 μg/ml) for 24 h before irradiation, then trypsinized and plated for clonogenic assay. Colonies were counted after 21 days and survival curves were constructed after normalizing for cytotoxicity induced from PBI-05204 alone. (A) Crystal violet staining of colonies from clonogenic assay in U251 cell lines. (B–E) Graphical representation of clonogenic assays of U251, U87MG, A172 and T98G GBM cells. Data are presented as mean ± SD (n = 4). ^a p < 0.05 comparison between PBI-05204 (2.5 μg/ml) + RT and RT only; *p < 0.05 comparison between PBI-05204 (5.0 μg/ml) + RT and RT only. (F) Radiation Enhancement Ratio (DER) of PBI-05204 in aforementioned GBM cells.