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. 2022 Mar 23;13:852941. doi: 10.3389/fphar.2022.852941

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Copyright © 2022 Colapietro, Yang, Rossetti, Mancini, Vitale, Chakraborty, Martellucci, Marampon, Mattei, Gravina, Iorio, Newman and Festuccia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PBI-05204 modified the responses of RT in human GBM cells mouse xenograft models. (A) Schematic representation of the treatment schedule of PBI-05204 (20 mg/kg/day) administered with a single dose of RT (4 Gy) at day 3 following start of treatment. (B) Representative U87MG tumors excised after 35 days (5 tumors/group). (C) Graphical representation of tumor growth curve and terminal tumor weight evaluation of U87MG tumors. (D) Graphical representation of terminal tumor weight of U251 tumors. (E) Graphical representation of terminal tumor weight of TG98 tumors treated with RT, PBI-05204 (20 mg/kg) and RT plus PBI-05204. Data are presented as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, δ p < 0.01 vs RT, and ° p < 0.05 vs PBI-05204.