TABLE 4.

Subgroup analysis of IL-6 diagnostic accuracy studies on EONS.

Subgroup			No. Studies	Pooled sensitivity, %	Pooled specificity, %
Study population	Preterm	All	13	83	82
		<30 pg/ml	6	80	81
		≥30 pg/ml	7	84	82
	Preterm and term	All	18	73	82
		<80 pg/ml	9	73	71
		≥80 pg/ml	9	73	90
Sample and timing	Cord blood	All	18	83	85
		UV	5	87	83
	Peripheral blood	All	12	71	77
		<48 h	6	80	77
		<1 week	6	64	77
Biomarker combinations	IL-6 + CRP		3	84	61

UV, umbilical vein.