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. 2022 Mar 23;13:814627. doi: 10.3389/fimmu.2022.814627

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Copyright © 2022 Ghanem, Shih, Khalili, Werth, Chakrabarty, Brown, Simpfendorfer and Gregersen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytokines/chemokines identified by LC-MS/MS and corresponding transcript presence in the scRNA-seq dataset. CXCL10 is a known pDC chemokine and is upregulated in pDCs upon flu virus treatment. CCL4 can be attributed to pDCs on the basis of upregulation with flu virus seen here. IFNG is not known to be a pDC cytokine, the absence of IFNG in the scRNA-seq dataset confirms the non-pDC origin of this cytokine in the secretome experiment. IL-16 is identified in the secretome data as enriched in the unstimulated condition. This finding is supported by the observation that ex vivo pDCs express IL16, whereas flu virus treated pDCs do not.