TABLE 1.
Demographics, neuropsychological tests and 18F-florbetapir PET imaging for NC, SCD, MCI, AD, and non-AD dementia.
| Index | NC (n = 183) | SCD (n = 77) | MCI (n = 111) | AD (n = 56) | Non-AD dementia (n = 22) | F/x2 (P-value) |
| Demographics | ||||||
| Age (years) | 61.99 ± 8.26 | 66.39 ± 4.54 | 65.11 ± 7.06 | 64.46 ± 7.09 | 64.27 ± 6.22 | 6.36 (<0.001) |
| Education (years) | 12.75 ± 2.92 | 12.09 ± 2.91 | 11.03 ± 3.16 | 8.49 ± 4.46 | 8.09 ± 3.22 | 26.13 (<0.001) |
| Gender (M:F) | 73:110 | 26:51 | 38:73 | 22:34 | 14:8 | 7.61 (0.107) |
| Diabetes [n (%)] | 27 (14.8%) | 13 (16.9%) | 13 (11.7%) | 7 (12.5%) | 5 (22.7%) | 2.35 (0.671) |
| Hypertension [n (%)] | 62 (33.9%) | 21 (27.3%) | 33 (29.7%) | 11 (19.6%) | 10 (45.5%) | 6.82 (0.145) |
| Hyperlipidemia [n (%)] | 33 (18.0%) | 13 (16.9%) | 16 (14.4%) | 7 (12.5%) | 3 (13.6%) | 1.41 (0.842) |
| Neuropsychological tests | ||||||
| MMSE | 28.21 ± 1.56 | 27.90 ± 1.60 | 26.51 ± 2.00 | 17.06 ± 5.12 | 19.90 ± 4.71 | 237.37 (<0.001) |
| MoCA-BC | 26.12 ± 2.39 | 25.52 ± 2.30 | 21.78 ± 3.38 | 13.06 ± 4.35 | 13.85 ± 4.68 | 238.38 (<0.001) |
| AVLT delayed recall | 5.81 ± 2.25 | 5.05 ± 2.15 | 2.31 ± 2.07 | 0.44 ± 0.75 | 2.09 ± 1.70 | 75.87 (<0.001) |
| AVLT recognition | 22.10 ± 1.51 | 21.64 ± 1.80 | 17.89 ± 2.73 | 14.84 ± 5.46 | 18.18 ± 2.08 | 96.61 (<0.001) |
| BNT | 24.75 ± 2.76 | 24.10 ± 2.86 | 21.21 ± 4.01 | 15.89 ± 6.71 | 18.45 ± 4.36 | 51.23 (<0.001) |
| AFT | 17.60 ± 3.99 | 15.69 ± 4.20 | 12.75 ± 3.22 | 9.26 ± 3.59 | 10.27 ± 2.61 | 53.13 (<0.001) |
| STT-A | 46.24 ± 14.46 | 45.48 ± 12.10 | 59.25 ± 28.65 | 82.26 ± 53.07 | 73.91 ± 28.87 | 20.38 (<0.001) |
| STT-B | 116.77 ± 33.65 | 127.40 ± 39.93 | 156.26 ± 50.63 | 171.17 ± 82.56 | 166.09 ± 70.62 | 18.98 (<0.001) |
| FAQ | 0.29 ± 0.91 | 0.77 ± 1.84 | 0.89 ± 2.20 | 6.12 ± 6.95 | 2.45 ± 2.66 | 43.17 (<0.001) |
| ECOG | 17.36 ± 5.83 | 18.33 ± 5.47 | 20.81 ± 7.90 | 29.86 ± 9.57 | 25.43 ± 8.77 | 34.22 (<0.001) |
| 18F-florbetapir PET positive | 38 (20.8%) | 27 (35.1%) | 43 (38.7%) | 56 (100%) | 0 (0%) | 129.88 (<0.001) |
NC, cognitively normal controls; SCD, subjective cognitive decline; MCI, mild cognitive impairment; AD, Alzheimer’s disease; MMSE, Mini-Mental State Examination; MoCA-BC, Chinese version of Montreal Cognitive Assessment-Basic; AVLT, Auditory Verbal Learning Test; BNT, Boston Naming Test; AFT, Animal Verbal Fluency Test; STT-A and B, Shape Trail Test Part A and B; FAQ, Functional Assessment Questionnaire; ECOG, Everyday Cognition; 18F-florbetapir PET, 18F-florbetapir positron emission tomography.