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. 2022 Mar 23;14:832700. doi: 10.3389/fnagi.2022.832700

TABLE 2.

Plasma Aβ42, Aβ40, Aβ42/Aβ40, t-tau, and 18F-florbetapir PET SUVR for NC, SCD, MCI, and non-AD dementia in individuals with Aβ-PET (−).

Plasma biomarkers NC (n = 145) SCD (n = 50) MCI (n = 68) Non-AD dementia (n = 22) F (P-value)
Aβ42 (pg/ml) 9.93 ± 3.01 9.30 ± 2.72 10.83 ± 2.89 11.65 ± 4.41 6.02 (0.001)
Aβ40 (pg/ml) 183.86 ± 44.15 184.61 ± 36.19 192.59 ± 52.05 209.01 ± 52.52 1.93 (0.124)
Aβ42/Aβ40 (ratio) 0.0557 ± 0.0172 0.0514 ± 0.0139 0.0585 ± 0.0200 0.0555 ± 0.0144 2.10 (0.101)
T-tau (pg/ml) 2.50 ± 1.23 2.29 ± 0.90 2.42 ± 1.00 2.32 ± 0.92 0.27 (0.844)
18F-florbetapir PET SUVR 1.19 ± 0.07 1.19 ± 0.07 1.17 ± 0.08 1.16 ± 0.09 0.18 (0.905)

NC, cognitively normal controls; SCD, subjective cognitive decline; MCI, mild cognitive impairment; AD, Alzheimer’s disease; 18F-florbetapir PET, 18F-florbetapir positron emission tomography; SUVR, standard uptake value ratios. P-values were adjusted for age, sex, and education years with general linear models. The bold values represented the values with statistical significance.