Table 1.

IBM parameter values.

parameter name	symbol	value	source
numerical parameters
initial number of agents	N(0)	30 000	experimental measurement (electronic supplementary material, S7)
initial number of red agents	Nr(0)	20 911	assumption (electronic supplementary material, S8)
initial number of yellow agents	Ny(0)	995	assumption (electronic supplementary material, S8)
initial number of green agents	Ng(0)	8094	assumption (electronic supplementary material, S8)
domain length	L	4000 μm	numerical experiments (electronic supplementary material, S4.3)
initial spheroid radius	$r_{\mathrm{o}}(0)$	245 μm	experimental measurement
dispersal distance	σ	12 μm	assumption (electronic supplementary material, S5)
migration distance	μ	12 μm	assumption (electronic supplementary material, S5)
simulation time	T	240 h	experimental measurement
per capita agent rates
maximum G1–eS transition rate	Rr	0.047 h–1	experimental measurement (electronic supplementary material, S6)
constant eS–S/G2/M transition rate	Ry	0.50 h–1	experimental measurement (electronic supplementary material, S6)
constant S/G2/M–G1 transition rate (mitosis)	Rg	0.062 h–1	experimental measurement (electronic supplementary material, S6)
maximum death rate	dmax	2 h–1	assumption
minimum death rate	dmin	0.0005 h–1	assumption
maximum migration rate	mmax	0.12 h–1	assumption
minimum migration rate	mmin	0.06 h–1	assumption
hill function index for arrest	η1	5	assumption
hill function index for migration	η2	5	assumption
hill function index for death	η3	15	assumption
nutrient parameters
number of nodes	I3	2013	assumption (electronic supplementary material, S4.4)
steady-state solution interval	t*	1 h	assumption (electronic supplementary material, S4.4)
consumption-diffusion ratio	α	0.15 μm cell–1	assumption
critical arrest concentration	ca	0.4	assumption
critical migration concentration	cm	0.5	assumption
critical death concentration	cd	0.1	assumption