TABLE 2.
Calculated interaction parameters for combinations of AZTTP with efavirenz or sefavirenza
| Drug(s) | Reference | Mean ± SD
|
||||||
|---|---|---|---|---|---|---|---|---|
| D50 (nM) | d1 (nM) | d2 (nM) | d1 + d2 (nM) | I
|
||||
| 50 | 20 | 90 | ||||||
| Efavirenz (d1) | 31 | 11 ± 2 | NA | NA | NA | NA | ||
| 10 | 13 ± 2 | NA | NA | NA | NA | NA | NA | |
| Sefavirenz (d1) | 31 | 25 ± 1 | NA | NA | NA | NA | ||
| 10 | 30 ± 1 | NA | NA | NA | NA | NA | NA | |
| AZTTP (d2) | 31 | 19 ± 2 | NA | NA | NA | NA | ||
| 10 | 21 ± 2 | NA | NA | NA | NA | NA | NA | |
| Efavirenz + AZTTP | 31 | NA | 5.9 ± 0.3 | 1.4 ± 0.2 | 7.3 ± 0.3 | 0.6 ± 0.2 | ||
| 10 | NA | 5.6 ± 0.3 | 1.5 ± 0.2 | 7.1 ± 0.3 | 0.5 ± 0.2 | 0.58 ± 0.05 | 0.4 ± 0.1 | |
| Sefavirenz + AZTTP | 31 | NA | 11.2 ± 0.2 | 2.8 ± 0.3 | 14 ± 1 | 0.68 ± 0.05 | ||
| 10 | NA | 13.6 ± 0.2 | 3.4 ± 0.3 | 17 ± 1 | 0.61 ± 0.05 | 0.64 ± 0.04 | 0.55 ± 0.1 | |
a
See the text for details. NA, not applicable. I50, I20, and I90, Berenbaum's I for 50, 20, and 90% inhibition, respectively.