Table 6.

Time-dependent AUCs and Brier Scores for the Different Survival Models in Younger (≤70 Years) and Older (>70 Years) Patients.

Model	Time (y)	≥70 y (N = 179)		<70 y (N = 302)
		AUC	Brier Score	AUC	Brier Score
17 genes (PC1 + PC2 + PC3 + PC4)	0.5	54.50	0, 099	75.42	0, 044
17 genes (PC1 + PC2 + PC3 + PC4)	1	64.85	0, 145	71.92	0, 095
17 genes (PC1 + PC2 + PC3 + PC4)	2	63.87	0, 181	74.01	0, 117
17 genes (PC1 + PC2 + PC3 + PC4)	5	65.13	0, 221	68.08	0, 154
COO + MHG	0.5	45.11	0, 103	58.17	0, 045
COO + MHG	1	54.23	0, 158	63.89	0, 098
COO + MHG	2	56.81	0, 196	67.01	0, 121
COO + MHG	5	54.76	0, 243	66.71	0, 155
IPI score	0.5	68.75	0, 098	78.00	0, 042
IPI score	1	73.43	0, 147	73.93	0, 091
IPI score	2	70.93	0, 182	76.11	0, 110
IPI score	5	68.50	0, 223	74.06	0, 142
IPI score + 17 genes (PC1 + PC2 + PC3 + PC4)	0.5	60.30	0, 096	81.93	0, 039
IPI score + 17 genes (PC1 + PC2 + PC3 + PC4)	1	70.01	0, 140	78.06	0, 084
IPI score + 17 genes (PC1 + PC2 + PC3 + PC4)	2	69.56	0, 173	81.30	0, 100
IPI score + 17 genes (PC1 + PC2 + PC3 + PC4)	5	68.96	0, 213	77.80	0, 133
IPI score + COO + MHG	0.5	59.42	0, 100	74.88	0, 041
IPI score + COO + MHG	1	68.64	0, 147	75.01	0, 088
IPI score + COO + MHG	2	68.79	0, 180	79.48	0, 105
IPI score + COO + MHG	5	65.98	0, 225	78.40	0, 133
IPI score + COO + MHG + 17 genes (PC1 + PC2 + PC3 + PC4)	0.5	57.31	0, 099	78.36	0, 039
IPI score + COO + MHG + 17 genes (PC1 + PC2 + PC3 + PC4)	1	68.11	0, 144	76.40	0, 085
IPI score + COO + MHG + 17 genes (PC1 + PC2 + PC3 + PC4)	2	67.60	0, 177	80.89	0, 100
IPI score + COO + MHG + 17 genes (PC1 + PC2 + PC3 + PC4)	5	66.48	0, 221	78.82	0, 131

Evaluated time points were 6 mo and 1, 2, and 5 y after diagnosis.

AUC = area under the curve; COO = cell-of-origin; IPI = International Prognostic Index; MHG = molecular high-grade; PC = principal component.