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. 2022 Mar 23;12:799678. doi: 10.3389/fcimb.2022.799678

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Copyright © 2022 Vindeirinho, Pinho, Azevedo and Almeida

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Genome organization of SARS-CoV-2. The ORFs constituting the SARS-CoV-2 RNA genome (from 5´ to 3´) encode the non-structural proteins (NSPs), which originate from ORF1a and ORF1b (ORF1ab), the spike (S), envelope (E), membrane(M) and nucleocapsid(N), as well as more than a handful of other dispersed and not-fully characterized accessory proteins (Kim et al., 2020; Hu et al., 2021). The ORFs that lead to accessory proteins include mainly ORF3, ORF6, ORF7, ORF8 and ORF10 (Michel et al., 2020; Giri et al., 2021). (B) Schematic representation of SARS-CoV-2 virion.