. 2022 Mar 23;14:852992. doi: 10.3389/fnagi.2022.852992

TABLE 3.

Changes in Clinical according to the fluctuator category reached at end of study.

Score	NF-C N = 24	F-C N = 13	F-U N = 14	NF-U N = 16	DK N = 7
ΔMDS-UPDRS III	8.5 (7.4)^****	6 (9.6)^*	1.5 (5) n.s.	6.6 (7.5)^**	4.7 (9.5)n.s.
ΔMDS-UPDRS IV	2.2 (3.1)^**	1.3 (3) n.s.	2.8 (4.5)^*	1.5 (4) n.s.	−0.4 (4.3) n.s.
ΔMDS-UPDRS Total	13.5 (11.3)^****	9.6 (13.5)^*	4 (7) n.s.	9.5 (11.5)^**	8.8 (15.6) n.s.
ΔPDQ39	6.6 (13.8)^*	7.3 (6.2)^**	1.2 (7.2) n.s.	2.7 (5.7) n.s.	1.1 (9.6) n.s.
ΔSENS	2.5 (4.5)^*	0.07 (3) n.s	1.5 (2.5)^*	0.9 (5) n.s.	−0.8 (7) n.s.
Δ Active BKS	3 (2.4)^****	2 (1.5)^***	1.9 (2.6)^**	1.1 (3.1) n.s.	−5.5 (3.3)^**
ΔPTB	18.7 (17.6)^****	17.3 (13)^***	10.4 (12.4)^**	6.1 (11.2)^*	30.4 (15.6)^**
ΔLEDD	−200 (278)^***	−267 (144)^****	−188 (180)^**	−340 (453)^**	−148 (185) n.s.
ΔD2	−64.5 (82.4)^***	−26 (56) n.s.	−16 (31) n.s.	15 (94) n.s.	−21.4 (36.6) n.s.

Δ = value of score at first visit—score at last visit, n.s. = p > 0.05, *0.05 > p > 0.01, **0.01 > p > 0.001, ***0.001 > p > 0.0001, ****0.0001 > p > 0.00001. P-values were obtained using the Paired t-test. Values are mean and SD.