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. 2022 Mar 23;13:822615. doi: 10.3389/fphar.2022.822615

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Copyright © 2022 Lu, Wang, Chen, Fan, Zhai, Fang, Cai, Liu, Wu and Cai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Olmesartan (Olm) can attenuate single-lung ventilation (SLV) induced lung injury. Lung histopathological alterations in rats in the S (sham) group; AS (ARB + sham) group, in which the rats given 7 days Olm treatment before the sham surgery; I (injury) group, in which the rats underwent SLV for 1 h (right lung ventilation and left lung collapsed) and double lungs ventilation for 3 h; and the AI (ARB + injury) group (hematoxylin and eosin staining; original magnification, ×400) (n = 6) (A). The lung injury score of HE staining in rats in each group (B). Lung W/D ratio in rats in all groups (C). IL-6 in plasma as shown by ELISA (D). Quantitative analysis of IL-6, IL-1β and TNF-α in HUVECs culture supernatant in different groups by ELISA (E–G) (n = 3). Quantitative analysis of IL-6, IL-1β and TNF-α in A549 cell culture supernatant by ELISA (H–J) (n = 3). Data are presented as the mean ± standard error of the mean. NS: not significantly different. *p < 0.05, **p < 0.005, ***p < 0.001, ****p < 0.0001. SLV: single-lung ventilation; Olm: olmesartan; ARB: angiotensin receptor blocker; S: sham; AS: ARB + sham; I: injury; AI: ARB + injury; Ctr: control; IR: ischemia reperfusion; W/D: wet/dry ratio; IL-6: interleukin-6; IL-1β: interleukin-1β; TNF-α: tumor necrosis factor-α; ELISA: Enzyme-linked immunosorbent assay.