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. 2022 Mar 23;13:822615. doi: 10.3389/fphar.2022.822615

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Copyright © 2022 Lu, Wang, Chen, Fan, Zhai, Fang, Cai, Liu, Wu and Cai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Olmesartan (Olm) inhibits SLV induced acute lung injury by inhibiting oxidative stress. MDA level in serum (A) The production of ROS was determined by flow cytometry (B–D) (n = 3). Representative images of HUVECs (B). Representative images of A549 cells (C). The average MFI of HUVECs (D). The average MFI of A549 cells (E). Data are presented as the mean ± standard error of the mean. NS: not significantly different. *p < 0.05, **p < 0.005, ***p < 0.001, ****p < 0.0001. SLV: single-lung ventilation; Olm: olmesartan; S: sham; AS: ARB + sham; I: injury; AI: ARB + injury; Ctr: control; IR: ischemia reperfusion; MDA: malondialdehyde; MFI: mean fluorescence intensity.