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. 2022 Mar 23;13:822615. doi: 10.3389/fphar.2022.822615

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Copyright © 2022 Lu, Wang, Chen, Fan, Zhai, Fang, Cai, Liu, Wu and Cai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The correlation between differential metabolites and lung microbiota. Correlation heat maps at both genus and species levels are mapped based on O2PLS analysis (A,B). The connections between the lung microbiota and metabolites at both levels are multiple (C,D). KEGG pathway annotation analysis of metabolism (E). Bubble chart from the top 20 pathways enriching with the most metabolites (F). The heat map of the top 20 most relevant pathways according to analysis of the microbial community (G). Venn diagrams of 24 shared pathways (H). Bubble chart from the 24 shared pathways (I). S: sham; AS: ARB + sham; I: injury; AI: ARB + injury; KEGG: Kyoto Encyclopedia of Genes and Genomes; O2PLS: Two-way Orthogonal Partial Least Squares.