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. 2007 Oct 17;2007(4):CD002181. doi: 10.1002/14651858.CD002181.pub2

Zeller 1991.

Methods RCT . 
 Mean duration 35 months , minimum 12 months.
Participants 47 type 1 patients with proteinuria over 500mg/24 hours , with diabetic retinopathy and no other cause of renal failure . 
 LPD mean age 33. Mean duration of diabetes 21 years. 
 UPD mean age 35. Mean duration of diabetes 22.4 years.
Interventions LPD = 0.6g / kg / ideal body weight/day (n=20). 
 UPD = at least 1 g/kg/day (n=15).
Outcomes GFR by iothalamate and creatinine. 
 Malnutrition measured by weight, mid‐arm circumference, and serum albumin. 
 Compliance assessed by uU and dietary history. Actual protein intake 0.72 g/kg/day.
Notes Malnutrition measures showed no significant change.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear

LPD: Low protein diet 
 UPD: Usual protein diet 
 EAA: Essential amino acids 
 TST: Triceps skinfold thickness 
 MAMC: Middle arm muscle circumference 
 GFR: Glomerular filtration rate 
 BMI: Body mass index 
 RR: Relative risk 
 ESRD: End‐stage renal disease 
 ACE: Angiotensin converting enzyme 
 RCT: Randomised controlled trial 
 Wt: Weight