Zeller 1991.
Methods | RCT . Mean duration 35 months , minimum 12 months. | |
Participants | 47 type 1 patients with proteinuria over 500mg/24 hours , with diabetic retinopathy and no other cause of renal failure . LPD mean age 33. Mean duration of diabetes 21 years. UPD mean age 35. Mean duration of diabetes 22.4 years. | |
Interventions | LPD = 0.6g / kg / ideal body weight/day (n=20). UPD = at least 1 g/kg/day (n=15). | |
Outcomes | GFR by iothalamate and creatinine. Malnutrition measured by weight, mid‐arm circumference, and serum albumin. Compliance assessed by uU and dietary history. Actual protein intake 0.72 g/kg/day. | |
Notes | Malnutrition measures showed no significant change. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Unclear risk | B ‐ Unclear |
LPD: Low protein diet UPD: Usual protein diet EAA: Essential amino acids TST: Triceps skinfold thickness MAMC: Middle arm muscle circumference GFR: Glomerular filtration rate BMI: Body mass index RR: Relative risk ESRD: End‐stage renal disease ACE: Angiotensin converting enzyme RCT: Randomised controlled trial Wt: Weight