Cytotoxic effects of 1–8 against several human cancer cell lines.
| Comp | IC50 (μM) | |||
|---|---|---|---|---|
| LU1 | HepG2 | MCF7 | SKMel2 | |
| 1 | 19.44 ± 1.48 | 29.35 ± 2.52 | 21.39 ± 1.04 | 12.91 ± 1.03 |
| 2 | 25.64 ± 2.34 | 21.43 ± 1.94 | 24.21 ± 1.37 | 21.70 ± 1.01 |
| 3 | 40.01 ± 1.52 | 36.82 ± 4.55 | 23.31 ± 2.43 | 34.01 ± 2.21 |
| 4 | >100 | >100 | >100 | >100 |
| 6 | 10.21 ± 1.68 | 7.53 ± 0.70 | 10.18 ± 1.60 | 9.93 ± 0.95 |
| 7 | 37.12 ± 3.46 | 44.46 ± 1.47 | 42.80 ± 1.08 | 27.63 ± 2.01 |
| 8 | >100 | >100 | >100 | >100 |
| aPos | 2.20 ± 0.20 | 2.07 ± 0.24 | 1.95 ± 0.16 | 1.18 ± 0.16 |
a
Ellipticine was used as a positive control.