Table 3.

Probes with the largest absolute magnitude of association with gestational age at birth

Probe	Chromosome	P-value	Gene	Direction of effect	Coefficienta	Standard error	Relation to island
cg10402321	1	3.11 × 10−36	UBXN11	−	−1.14 × 10-2	7.60 × 10−4	Open Sea
cg04441405	5	6.60 × 10−38	−	−	−1.10 × 10−2	7.13 × 10−4	Island
cg07167946	5	1.94 × 10−32	IRX4	−	−9.85 × 10−3	7.13 × 10−4	Island
cg07803375	7	3.6 × 10−22	HEATR2	−	−9.08 × 10−3	8.50 × 10−4	North Shelf
cg14670058	13	9.24 × 10−23	SMIM2	−	−9.07 × 10−3	8.35 × 10−4	Open Sea
cg16051275	6	7.53 × 10−36	−	+	1.23 × 10−2	8.30 × 10−4	Open Sea
cg11460314	20	4.21 × 10−20	ZBP1	+	1.24 × 10−2	1.24 × 10−3	Open Sea
cg04118102	17	1.00 × 10−30	−	+	1.31 × 10−2	9.86 × 10−4	South Shelf
cg17368297	16	1.55 × 10−25	−	+	1.40 × 10−2	1.20 × 10−3	Open Sea
cg14576951	7	6.73 × 10−30	INTS1	+	1.44 × 10−2	1.10 × 10−3	Island

^a Coefficient corresponds to methylation change per week of gestation.