Table 4.
Predictors for microvascular complications
| Variable | Diabetic retinopathy |
Microalbuminuria |
||||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P-value | Adj. HR† (95% CI) | Adj. P-value | HR (95% CI) | P-value | Adj. HR† (95% CI) | Adj. P-value | |
| Age at diagnosis (yr) | 1.33 (0.98–1.81) | 0.070 | 1.54 (0.93–2.55) | 0.096 | ||||
| Mean HbA1c (%)‡ | 4.84 (1.97–11.92) | <0.001 | 3.78 (1.19–12.03) | 0.024 | ||||
| Puberty at diagnosis | 8.48 (1.10–65.67) | 0.041 | 524.01 (0.00–2.70) | 0.490 | ||||
| 24-Hour sBP SDS | 1.28 (0.69–2.38) | 0.430 | 1.92 (0.16–23.13) | 0.608 | 0.91 (0.37–2.25) | 0.845 | 0.62 (0.12–3.19) | 0.570 |
| 24-Hour dBP SDS | 1.13 (0.54–2.36) | 0.739 | 1.40 (0.38–5.14) | 0.613 | 1.49 (0.60–3.66) | 0.389 | 2.36 (0.29–18.95) | 0.420 |
| 24-Hour MAP SDS | 1.33 (0.72–2.45) | 0.367 | 0.97 (0.35–2.68) | 0.960 | 1.3 (0.56–3.00) | 0.536 | 1.25 (0.28–5.59) | 0.770 |
| Daytime sBP SDS | 1.12 (0.59–2.12) | 0.728 | 0.55 (0.16–1.90) | 0.347 | 0.86 (0.33–2.23) | 0.759 | 0.75 (0.16–3.53) | 0.720 |
| Daytime dBP SDS | 0.89 (0.43–1.83) | 0.751 | 0.89 (0.30–2.66) | 0.835 | 1.24 (0.49–3.13) | 0.643 | 1.91 (0.32–11.41) | 0.478 |
| Daytime MAP SDS | 0.97 (0.48–1.95) | 0.930 | 0.73 (0.26–2.07) | 0.555 | 1.07 (0.40–2.83) | 0.891 | 1.20 (0.29–4.99) | 0.806 |
| Nighttime sBP SDS | 1.64 (0.87–3.09) | 0.128 | 1.06 (0.33–3.44) | 0.917 | 0.88 (0.34–2.26) | 0.794 | 0.40 (0.08–2.14) | 0.285 |
| Nighttime dBP SDS | 1.64 (0.73–3.67) | 0.230 | 3.21 (0.51–20.35) | 0.216 | 1.41 (0.46–4.36) | 0.550 | 0.64 (0.09–4.46) | 0.651 |
| Nighttime MAP SDS | 1.56 (0.82–2.97) | 0.179 | 1.63 (0.48–5.60) | 0.437 | 1.08 (0.43–2.73) | 0.865 | 0.50 (0.10–2.67) | 0.413 |
HR, hazard ratio; CI, confidence interval; HbA1c, glycated hemoglobin A; sBP, systolic blood pressure; SDS, standard deviation score; dBP, diastolic blood pressure; MAP, mean arterial pressure.
†
Multivariate analysis with adjusting age at diagnosis and average HbA1c level.
‡
Average HbA1c from diagnosis to last follow-up.