Table 4.
Response to pamidronate treatment in 22 patients with osteogenesis imperfecta
| Variable | Initial | Final | P-value |
|---|---|---|---|
| Age (yr) | 10.2±9.6 | 12.8±9.7 | |
| Annual fracture frequency | 3.2±10.5 | 0.4±0.8 | 0.008 |
| Height SDS | -1.6±1.3 | -1.5±1.3 | 0.185 |
| Lumbar BMD z-score | -2.2±3.3 | 1.0±4.4 | 0.001 |
| Femoral neck BMD z-score | -3.1±2.2 | -0.6±1.9 | 0.001 |
| Calcium (mg/dL) | 9.6±0.7 | 9.4±0.5 | 0.038 |
| Phosphorus (mg/dL) | 5.1±1.0 | 4.8±0.8 | 0.060 |
| ALP (IU/L) | 251.1±95.6 | 188.0±81.4 | 0.001 |
| PTH (pg/mL) | 31.6±19.2 | 27.6±18.0 | 0.210 |
| Osteocalcin (ng/mL) | 71.6±55.7 | 71.4±64.0 | 0.929 |
Values are presented as mean±standard deviation.
SDS, standard deviation scores; BMD, bone mineral density; ALP, alkaline phosphatase; PTH, parathyroid hormone.