Table 2.
Growth response after growth hormone treatment
| Parameter | All patients (n = 692) | ISS (n = 98) | Partial GHD (n = 443) | Complete GHD (n = 151) | P-value | Post hoc * | |
|---|---|---|---|---|---|---|---|
| Ht velocity (cm/yr) | |||||||
| 1st year | 9.09±1.65 | 8.72±1.64 | 9.04±1.55 | 9.52±1.93 | 0.181 | ||
| 2nd year | 7.48±1.41 | 6.97±0.75 | 7.41±1.44 | 7.99±1.43 | 0.050 | ||
| During 2 years | 8.28±1.15 | 8.27±1.09 | 8.19±1.08 | 8.55±1.36 | 0.451 | ||
| ΔHt-SDS | |||||||
| 1st year | 0.85±0.39 | 0.78±0.40 | 0.83±0.34 | 0.96±0.51 | 0.218 | ||
| 2nd year | 0.41±0.27 | 0.29±0.14 | 0.39±0.26 | 0.53±0.34 | 0.032 | a>b, c | |
| During 2 years | 1.26±0.50 | 1.24±0.47 | 1.20±0.41 | 1.42±0.70 | 0.235 | ||
| ΔBMI-SDS | |||||||
| 1st year | -0.23±0.58 | -0.25±0.62 | -0.23±0.57 | -0.19±0.58 | 0.667 | ||
| 2nd year | 0.03±0.42 | -0.04±0.49 | 0.03±0.36 | 0.03± 0.56 | 0.765 | ||
| During 2 years | -0.18±0.59 | -0.31±0.52 | -0.18±0.61 | -0.13±0.54 | 0.640 | ||
| Δ (BA−CA) | |||||||
| 1st year | -0.24±1.02 | -0.31±0.77 | -0.22±1.08 | -0.23±0.96 | 0.939 | ||
| 2nd year | 0.36±0.98 | 0.07±0.73 | 0.34±1.02 | 0.54±0.94 | 0.363 | ||
| During 2 years | 0.16±1.28 | -0.26±1.19 | 0.17±1.23 | 0.31±1.44 | 0.275 | ||
Values are presented as mean±standard deviation.
ISS, idiopathic short stature; GHD, growth hormone deficiency; Ht, height; SDS, standard deviation score; BMI, body mass index; BA, bone age; CA, chronological age.
*
Multiple comparsion: Bonferroni (a=ISS; b=partial GHD; c=complete GHD).