Figure 2.

Mechanism of Ferroptosis Inhibition. SLC7A11 gene is a sodium-dependent antiporter responsible for Glutathione synthesis. The gene encodes a xCT system which imports one Cystine molecule by simultaneous export of Glutamate molecule. The transporter activity of SLC7A11 gene is stabilised by a chaperon encoded by SLC3A2 gene. Once cystine enter into the cytoplasm of the cell it is reduced to cysteine and contributes to the formation of Glutathione with Glycine and Glutamate. The Glutathione serves as a co-factor for the enzyme GPX-4 which inhibits the formation of lipid peroxides there by protecting the cells from ferroptosis and permitting cell proliferation.