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IC50 (µM) and multicellular resistance index (MCRI) values for LNCaP-Luc cell cultures (n=3 independent experiments; mean ± SD)
| Docetaxel | TH-302 | |||
|---|---|---|---|---|
|
|
|
|||
| IC50 (µM) | MCRI | IC50 (µM) | MCRI | |
| Monolayer cells | 2.7±1.2 | / | 7.8±8.3 | / |
| Day 3 spheroid | 29.6±9.5 | 11.1 | 7.5±6.8 | 1.0 |
| Day 7 spheroid | 57.0±24.9 | 21.3 | 1.9±1.7 | 0.2 |
| Day 14 spheroid | 96.0±11.9 | 36.0 | 5.5±3.5 | 0.7 |
